Methodology

This consensus statement presents a synthesis of evidence from the published literature and scientific abstract presentations available at the time of writing, relevant to the Australian PBS listing for HCV medications at the time of writing. Levels of evidence for recommendations have been graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.126 The quality of the evidence in the recommendations has been classified into one of three levels: high (A), moderate (B) or low (C). The GRADE system offers two grades of recommendation: strong (1) or weak (2).

Evidence qualityNotesGrade
HighFurther research is very unlikely to change our confidence in the estimate of effect.A
ModerateFurther research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.B
LowFurther research is very likely to have an important impact on our confidence in the estimate and is likely to change the estimate. Any change of estimate is uncertain.C
RecommendationNotesGrade
StrongFactors influencing the strength of the recommendation included the quality of the evidence, presumed patient-important outcomes and cost.1
WeakVariability in preferences and values, or more uncertainty. Recommendation is made with less certainty, higher cost or higher resource consumption.2

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