Consensus recommendations for screening and diagnosis

Consensus recommendationsGrade
HCV seronegative people with risk factors for HCV transmission should be screened annually for HCV infection.A1
The appropriate screening test for HCV infection is HCV serology (HCV antibodies).A1
If HCV antibodies are detected, current infection should be confirmed by testing for HCV RNA using a sensitive PCR assay.A1
Chronic HCV infection is defined by repeated HCV antibody positivity and HCV RNA positivity with a duration of infection longer than 6 months.A1
HCV seropositive people with undetectable HCV RNA (either spontaneous or after treatment) and with ongoing risk factors for HCV transmission should be screened annually for HCV infection with HCV RNA (PCR).A1
All individuals with chronic HCV infection should be tested for HCV genotype.A1

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